For the sixth year in a row, the Australian city has topped the Economist Intelligence Unit's ranking of the world's most livable cities.
The list, which considers stability, healthcare, culture and environment, education and infrastructure to arrive at a rating out of 100, gave Melbourne an overall score of 97.5.
Close behind is the Austrian capital Vienna, with 97.4, and Canada's Vancouver with 97.3 — positions both cities also held in 2015.
While little has changed among the ranks of the most comfortable cities, it's a darker picture elsewhere in the world with instability, terrorism and conflict causing several formerly "safe" destinations to lose their sheen.
Among them is the French capital Paris, which has seen its livability score drop by 3.7% over the past five years, a situation not helped by recent terror attacks in the city.
Paris is joined on its downward journey by Moscow, St. Petersburg, Athens and Caracas.
"Although the top five cities remain unchanged, the past year has seen increasing instability across the world, causing volatility in the scores of many cities," the EIU's annual ranking report summary says.
"The continuing weakening of global stability scores has been made uncomfortably apparent by a number of high-profile incidents that have not shown any signs of slowing in recent years," it adds.
Inevitably, the world's least livable cities are those blighted by war, poverty and political turmoil -- or all three.
Syria's capital Damascus ranks bottom of the 140 cities scored with a rating of 30.2. Just above it is Libya's Tripoli with 35.9 and the sprawling Nigerian megacity of Lagos, with 36.
Some cities are improving, though. The Iranian capital Tehran, which is benefiting from improved ties with the West after years of sanctions, has seen a 5% rise in its score over five years.
Zimbabwe's capital Harare, blighted by years of runaway inflation and political unrest, has seen a 4.4% improvement, although it still languishes near the tail end of the livability chart in 133rd place.
Most livable cities:
1. Melbourne, Australia
2. Vienna, Austria
3. Vancouver, Canada
4. Toronto, Canada
=5. Calgary, Canada
=5. Adelaide, Australia
7. Perth, Australia
8. Auckland, New Zealand
9. Helsinki, Finland
10. Hamburg, Germany